Episode 492: Clash of Red and Black! (Blood Relative)
Scenario: Kōshi confirms that the picture is indeed Rena and shows them a news recording depicting Rena with the same hairstyle as Eisuke's sister's in the photograph. In the video, they learn that Rena's blood type is AB. Eisuke denies that Rena is his sister since his sister's blood was once used for his blood transfusion; Eisuke has blood type O, meaning he can only receive Type O blood. Conan suspects there is a hidden component to Eisuke's story and believes Eisuke is searching for Rena with an ulterior motive. The next day, Eisuke invites Ran and Sonoko to accompany him to the mansion he used to live in to collect his mother's belongings which were recently found. Kogoro, coincidentally, was also hired to investigate a murder at the mansion that occurred a year ago. Once there, Eisuke finds his birth certificate, confirming that he has blood type O. Meanwhile, Kogoro is with the owner of the mansion, Kakuzō Okudaira, discussing the murder of his son, Tango Okudaira. Kakuzō tells Kogoro he suspects the murderer is one of three people in the mansion.